Abstract
Introduction: Dengue infection is caused by the dengue virus (arbovirus), the incidence of which is increasing in India. In dengue endemic settings, early diagnosis and monitoring for complications are important, especially in children. Concurrent testing of NSI antigen, dengue specific IgG and IgM will help to diagnose patients with suspected dengue fever. Objective: To correlate the clinical profile and outcome of dengue fever with detection of NSI antigen, dengue specific IgG and IgM antibody, hematological and biochemical parameters and blood component utilization. Methods: All children presenting to Rainbow hospital and diagnosed with dengue infection using NS1 and dengue specific IgG and IgM antibody during a one year period (1st November 2016 to 31st October 2017) were included in the study. The haemogram and biochemistry parameters were done using automated analyzers. Inpatients were classified as severe or non-severe based on clinical and/or laboratory evidence. The degree of association between clinical parameters and disease severity in relation to NS1 positivity was expressed as an odds ratio. Results: Among 213 children diagnosed, 126 were treated as inpatients and the rest as outpatients. The age range of the study sample was 6 months to 15 years. NS1 positivity was observed in 72.3 % patients. NS1 positivity, when compared to severity of disease was significant (Odds ratio: 2.3; p Conclusions: Using all three tests (NS1, dengue specific IgM and IgG) was useful, as in 59 (27.7%) patients, despite a negative NS1, based on a positive dengue antibody response (IgG and/or IgM), the patients were admitted and monitored. NS1 positivity was associated with a higher risk of thrombocytopenia in this study.
Highlights
Dengue infection is caused by the dengue virus, the incidence of which is increasing in India
NS1 positivity was associated with a higher risk of thrombocytopenia in this study
A total of 213 children were diagnosed with acute dengue infection during the study period, among whom 126 were treated as inpatients and the rest as outpatients based on clinical and laboratory parameters
Summary
Dengue infection is caused by the dengue virus (arbovirus), the incidence of which is increasing in India. Early diagnosis and monitoring for complications are important, especially in children. Dengue infection is an arboviral disease caused by the dengue virus. Dengue is increasing in incidence in India and is associated with significant morbidity and mortality.[1] In India, the annual incidence is estimated to be 7.5 to 32.5 million.[1,2] At present there is no effective antiviral treatment or vaccine to prevent infections. In a dengue endemic setting, early diagnosis and monitoring for complications are important. There are very few studies in India based on the revised WHO dengue classification for management.[3,4,5]
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