Correlation of B-type natriuretic peptide with blood lipids and renal function in elderly patients with coronary heart disease

Abstract

Objective To explore the correlation of B-type natriuretic peptide (BNP) with blood lipids and renal function in elderly patients with coronary heart disease (CHD). Methods According to the four quantiles of BNP level, 325 subjects aged 65 years and over were divided into four groups: group A (≤32.4 ng/L), group B (32.5 ng/L), group C (62.4 ng/L), group D (>162.5 ng/L). The left ventricular ejection fraction (LVEF), left ventricular end-diastole dimension (LVEDD), levels of blood lipids and renal function were compared among the groups. Results With the increase of BNP level, the LVEF was gradually decreased 〔(63.3±8.2)%, (59.6±7.4)%, (57.9±9.7)%, (55.2±10.6)%, respectively, F=11.54, P<0.01〕 and the LVEDD was gradually increased (F=6.76, P<0.01), the level of triglyceride (TG) was gradually decreased (F=2.73, P<0.05) in group A, B, C and D. Creatinine clearance was gradually decreased 〔(1.24±0.31) ml·s-1·1.73 m-2, (1.21±0.31) ml·s-1·1.73 m-2, (1.24±0.29) ml·s-1·1.73 m-2, (1.09±0.33) ml·s-1·1.73 m-2, respectively, F=3.62, P<0.05〕, and blood urea nitrogen was gradually increased (F=4.43, P<0.05) in group A, B, C and D. Multi-linear regression analysis showed that levels of total cholesterol, triglyceride, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, creatinine clearance and blood urea nitrogen were influencing factors for BNP (all P<0.05). Conclusions BNP level can be used as a sensitive indicator for the diagnosis of heart failure and the assessment of its severity. The levels of blood lipids and renal function are associated with BNP. Key words: Coronary disease; Natriuretic peptide, brain; Lipid metabolism