Abstract
Objective To investigate the correlation between AS160 hyperphosphorylation and 18F-fluorodeoxyglucose (18F-FDG) uptaking in invasive breast cancer. Methods Thirty-nine primary breast caner patients received PET/CT scan before operation and their maximum standard uptake values (SUVmax) were recorded. The levels of p-AS160 (Thr642) were detected using immunohistochemical method in breast cancer tissues. The association between p-AS160 (Thr642) levels and SUVmax was assessed using the Spearman nonparametric test. Results The 18F-FDG uptake of tumors of the 39 patients with primary breast caner was 6.1±2.7 (SUVmax). There was one false negative case in PET/CT scan imaging, compared with postoperative pathologic result. The positive rate of p-AS160 (Thr642) was 76.9%, and it was positively correlated with SUVmax (r=0.672, P<0.001). Conclusion AS160 plays a significant role in the glucose metablism of breast cancer tissues and its hyperphosphorylation may contribute to the increased uptaking of glucose in patients with breast cancer. Key words: Breast neoplasms; Phosphorylation; Fluomdeoxyglucose F18; AS160
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