CORRELATION OF ARSENIC AND HESPERIDIN ON BLOOD PRESSURE IN WISTAR RAT.

Abstract

Background: Arsenic causes various health problems including cardiovascular abnormalities through contaminated drinking water and environmental exposure. Arsenic cardiovascular toxicity is the major concern nowadays. Hesperidin, a avonoid, may alter the Arsenic induced toxicity. Objectives: The aim of our study was to nd out the protective role of hesperidin against Arsenic exposure effects on blood pressure in wistar rats. Materials and Methods: Eighteen male wistar rats were procured from Indian Institute Of Toxicology and Research (CSIR-IITR), Lucknow, UP. Rats were divided into three groups equally (n=6). Group-Awere taken as control, Animals of Group B were treated with Sodium Arsenite, while Sodium Arsenite and Hesperidin was given to animals of Group C in desired doses. Blood Pressure was measured with NIBP(Non Invasive Blood Pressure) Monitoring machine before starting of treatment and at the every end of weeks for four successive weeks. Results: In our present study we found that the effect of Arsenite and hesperidin was statistically signicant. Results showed that the systolic blood pressure was raised by treatment with sodium arsenite and the hesperidin was able to reduce the arsenite induced increment of blood pressure in wistar rats. Conclusion: There exist a signicant increase of systolic blood pressure with Sodium Arsenite and Hesperidin protects against rise in systolic blood pressure.