Correlation of ApoE gene polymorphism and serum uric acid in Ningxia Hui Autonomous Region

Abstract

Objective Toexplore the correlation of ApoE gene polymorphism and serum uric acid levels in Ningxia Hui Autonomous Region,China. Methods A case-control study.October 2011 to November 2011，five hundred twenty eight (296 male,232 female) apparently healthy individuals were studied.Questionnaires and physical examinations were performed by standard operation procedure.Fasting blood was collected for biochemistry testing including serum lipid parameters,uric acid concentration and creatinine levels.The multi-ARMS PCR was applied to determine ApoE genotypes,and the relation of ApoE genotypes with serum lipid parameters and uric acid levels were analyzed.Non-normal distribution were compared using cause and inspection. Results The common six kinds of ApoE genotype can be detected.The total cholesterol (TC),low density lipoprotein cholesterol (LDL-C) and uric acid (UA) levels in different genotype subgroups had statistical differences.The individuals with e2/3 genotype had a significantly greater reductions in TC and LDL-C levels but increment in uric acid concentration than those with e3/3 and e3/4 genotype (P<0.05).The effect of ApoE gene polymorphism on uric acid levels still remained significantly after adjustment for age,gender,region and other factors. Conclusion The ApoE polymorphism is associated with serum uric acid levels and individuals with e2 allele have higher serum uric acid levels.（Chin J Lab Med，2014,37：434-438） Key words: Apolipoproteins E; Polymorphism,genetic; Uric acid; Lipid metabolism