Correlation of anthropometric indicators for identifying insulin sensitivity and resistance.

Lívia Nascimento Matos,Guilherme De Vieira Giorelli,Cristiane Bitencourt Dias

doi:10.1590/s1516-31802011000100006

Lívia Nascimento Matos, Guilherme De Vieira Giorelli + Show 1 more

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https://doi.org/10.1590/s1516-31802011000100006

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Abstract

Early detection of reduced insulin sensitivity (IS) and insulin resistance (IR) is desirable. The aim here was to evaluate correlations of anthropometric indicators for identifying IR or IS and determine the cutoff points of the most effective indicators. Cross-sectional study in the city of São Paulo. Sixty-one individuals with normal fasting plasma glucose (NFPG) and 43 overweight women were analyzed. Body mass index (BMI), waist circumference (WC), waist-to-hip ratio, waist-to-height ratio (WHtR), conicity index and the HOMA-IS and HOMA-IR indices were determined. The correlations between the anthropometric indices and IS and IR were determined. ROC analysis was used to determine the areas under the curve (AUC) and cutoff points. Among the NFPG individuals, BMI (r = -0.50; P = 0.002) and WHtR (r = -0.45; P = 0.007) showed correlations with HOMA-IS (homeostasis model assessment of insulin sensitivity). The ROC curve demonstrated statistical significance for BMI (AUC = 0.769; P = 0.005), WHtR (AUC = 0.764; P = 0.01) and WC (AUC = 0.702; P = 0.04), and the best cutoff points were 33.3 kg/m², 0.67 and 100 cm, respectively. Among the overweight women, the best correlation with HOMA-IR was demonstrated by WHtR (r = 0.37; P = 0.01), and the best cutoff point was 0.70 (AUC = 0.61; P = 0.25). The most promising indicators for showing IS among the NFPG individuals were BMI, WHtR and WC. Among the overweight women, WHtR demonstrated greater correlation with IR.

Highlights

Over recent decades, it has come to be considered that there is a worldwide pandemic of diabetes mellitus (DM)
We evaluated 43 non-diabetic females, of mean age 57.2 ± 12.9 years, who were either overweight or presented abdominal and generalized obesity
A ROC curve was constructed for the anthropometric indicators evaluated and HOMA-insulin sensitivity (IS) was calculated in order to assess IS

Summary

Introduction

It has come to be considered that there is a worldwide pandemic of diabetes mellitus (DM). Data from the World Health Organization (WHO) indicate that the prevalence of DM is 2.8% among the worldwide population over 20 years of age.[1] Prediabetes, characterized by abnormal fasting plasma glucose, glucose intolerance, or both, is often asymptomatic and the time that elapses between the early stages of these conditions and the diagnosing of DM ranges from four to seven years.[2] Over this period, the complications relating to inadequate glucose metabolism progress and tissue damage becomes established before DM is diagnosed.[3,4,5,6] Within this context, early detection of alterations in glucose metabolism is desirable, such that prophylactic interventions can be implemented.[7,8,9].

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