Abstract
Breast density is a significant predictor in the risk of developing breast cancer. Several methods are available for assessing breast density but all are subject to intra-observer variability and are unable to assess the breast as a three-dimensional structure. Using Quantra™ to quantify breast density, we have correlated this with risk factors to determine what impact these variables have on breast density. Women attending for full-field digital mammography at the South West London Breast Screening Unit between December 2008 and March 2009 were invited to participate in the study by questionnaire. Consenting women returned the questionnaire, allowing further data collection, including demographics, menopausal status and hormone replacement therapy use. Data were correlated against breast density measurements to determine the degree of association. Mammograms were assessed on a Hologic™ workstation and breast density calculated using Quantra™. Quantra™ is an automated algorithm for the volumetric assessment of breast tissue composition from digital mammograms. We invited 683 women to participate (those with implants or mastectomy were excluded) and 321 completed returned questionnaires were assessed. The mean age of participants was 59 years (range 49 to 81). Mean density was 19.4% (range 8.5 to 49.0%). There was a decrease in density with age (Spearman rank correlation coefficient - 0.21). Correlation between density and hormone replacement therapy use showed a significant positive result. Quantra™ has shown to be an accurate, reproducible tool for quantifying breast density, demonstrated by its correlation with lifestyle and demographic data. Given its ease of acquisition, this may be the future of breast density quantification in the digital age.
Highlights
The aim of the study was to assess real life reader performance as a function of volume of mammograms read in a large multicentre cohort
This study examined the effect of arbitration of indeterminate mammograms only following consensus decision to recall
The data demonstrated that participants were as able to identify abnormalities without the need of using image enhancement manipulations as they were with them (P > 0.5)
Summary
The aim of the study was to assess real life reader performance as a function of volume of mammograms read in a large multicentre cohort. The standard technique for surgical excision of mammographically detected, ultrasound invisible, non-palpable breast lesions is by pre-operative stereotactic guidewire localization (SGL). Methods Between September 2007 and June 2009, 15 patients with mammographically detected, non-palpable, ultrasound invisible breast lesions had VACB followed by HUGL We compared this technique with 15 consecutive patients who underwent SGL. This study was performed to compare the ipsilateral post-operative mammography findings, frequency of ultrasound and image-guided biopsy post-TM with a group of women who had undergone wide local excision (WLE). Methods Between August 2004 and March 2009, 41 cases of ductal carcinoma in situ (DCIS) were retrospectively identified from the screen-detected cases of microcalcifications who underwent stereotactic WBN biopsy with a 14g automated device The histology from these cases was compared with the post-surgery histology
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