Correlation of a novel research cardiovascular profiling system with ambulatory blood pressure monitoring

Abstract

The elasticity of the vessels affects the shape of the blood pressure waveform. Not many studies analyze a relation between such evaluation and Ambulatory Blood Pressure Monitoring (ABPM). AIMS: 1. To determine the prevalence of abnormal large and/or small artery elasticity index (AEI). 2. To determine its correlation with ABPM. N=69, aged 31–81 (60,49+-1,63), M/F ratio= 39/30, 40 hypertensive.Large (C1) and small (C2), AEI, systemic vascular resistance, total vascular impedance. HDI/PulseWave CR-2000. ABPM : Activity, rest and critical (06:00–9:00am) periods: average systolic BP (aSBP), average diastolic BP (aDBP), average Mean Arterial Pressure –MAP-, Ambulatory pulse pressure (APP). Systolic and diastolic BP burden (systolic>125 and diastolic>75 mmHg pressure reading percentages) (SBPB and DBPB). Hemodynamic load (HL=Heart Rate x MAP/100). SBP variability (SBPV) and DBP variability (DBPV). HR variability (HRV). Statistical: t-Student, Levene’s, Mann-Whitney U test. 1- The prevalence of abnormal C1 was 36,2% (N=25). We found differences in age (p <0,001) and in the following parameters: aDBP during global, activity, and rest periods (p=0,003; p=0,004; p=0,014) as well as in DBPB: (p=0,004) and APP: (p=0,004). 2- The prevalence of abnormal C2 was 49,3% (N=34). These patients were older than those with normal elasticity (p = 0,003). 3- In relation to C2 values we found a statistically significant difference between both groups in the following parameters: SBPV during global (p=0,001), activity (p=0,021) and rest (p=0,009) periods, as well as in HRV in the rest period: p= 0,032. In the critical period there was a significant difference in SBP and MAP with higher values in those with abnormal elasticity (p=0,013)(p=0,04). 1. The prevalence of stiffness in large and small arteries was of 36,2% and 49,3% respectively.2. The stiffness of large arteries in indirectly related to DBP but directly related to ambulatory measure of APP. 3. The stiffness of small arteries is related in an opposite way to SBP variability (increase), and HRV (decrease), and in a direct way to SBP in the critical period. That is why we conclude that this method is able to select a very high risk population.