Abstract
Background and purposeThe aim of this study was to compare the accumulation of 4-borono-2-18F-fluoro-phenylalanine (18F-BPA) with that of 18F-fluorodeoxyglucose (18F-FDG) in head and neck cancers, and to assess the usefulness of 18F-FDG PET for screening candidates for boron neutron capture therapy (BNCT). Material and methodsTwenty patients with pathologically proven malignant tumors of the head and neck were recruited from March 2012 to January 2014. All patients underwent both whole-body 18F-BPA PET/CT and 18F-FDG PET/CT within 2weeks of each other. The uptakes of 18F-BPA and 18F-FDG at 1h after injection were evaluated using the maximum standardized uptake value (SUVmax). ResultsThe accumulation of 18F-FDG was significantly correlated with that of 18F-BPA. The SUVmax of 18F-FDG ⩾5.0 is considered to be suggestive of high 18F-BPA accumulation. Conclusions18F-FDG PET might be an effective screening method performed prior to 18F-BPA for selecting patients with head and neck cancer for treatment with BNCT.
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