Correlation Intramural Vascular Invasion and Extramural Vascular Invasion with Histopathological Grading of Adenocarcinoma Colorectal

Abstract

Background: Carcinoma colorectal is a malignancy originating from the colorectal epithelium which ranks the third-largest in the world after lung and breast cancer, leading to the highest mortality in the world with new cases of about 1.8 million (10.2%). Ninety percent of colorectal malignancies are a type of adenocarcinomas. Vascular invasion of the adenocarcinoma of the colorectal could be one of the most damaging prognostic indicators and can be helpful for the selection of adjuvant chemotherapy. Material and methods: This study is a sectional cross-sectional study conducted on 35 patients with adenocarcinoma colorectal taken from their formalin-fixed paraffin-embedded tissue blocks in period 2018-2019, which is colorectal by hematoxylin and eosin to assess intramural vascular invasion and extramural with histopathology grade of adenocarcinomas. Sample characteristic data from a medical file was retrieved. Mann-Whitney test u (p< 0.005) is used to assess the correlation of intramural vascular invasion and extramural vascular invasion with histopathological grade. Results: Among 35 samples of those with adenocarcinomas of colorectal, the most cases were low grade by 30 cases (85.7%) and vascular invasions have been found in common, both intramural and intramural and extramural as many as 10 cases (26.6%). Mann-Whitney U correlation test and found a significant correlation between intramural and extramural vascular invasion with histopathological grade (p = 0.001) Conclusion: There is a significant correlation of statistical analysis between intramural and extramural vascular invasion and histopathology grade of adenocarcinomas colorectal. Keywords: adenocarcinomas colorectal, intramural vascular invasion, extramural vascular invasion, grade.