Abstract
Both type 1 and type 2 diabetes mellitus have been associated with vitamin D deficiency. Diabetic ketoacidosis, which is a complication of type 1 and, rarely, type 2 diabetes, is also found to be associated with vitamin D levels. This review discusses studies on the correlation between diabetic ketoacidosis and vitamin D levels. Studies show that vitamin D deficiency is associated with the occurrence of diabetic ketoacidosis. Diabetic ketoacidosis is also found to affect vitamin D levels. The possible explanation of diabetic ketoacidosis affecting vitamin D levels is the inactivity of the 1-alpha-hydroxylase enzyme and an increase in the renal excretion of vitamin D binding proteins. The presence of vitamin D receptors on pancreatic beta cells explains the role of vitamin D in the causation of diabetic ketoacidosis.
Highlights
BackgroundVitamin D deficiency is prevalent around the globe, with an estimated one billion people being vitamin D deficient [1]
Diabetic ketoacidosis is a complication of uncontrolled type 1 diabetes mellitus, which results from insulin deficiency or excess of adrenaline or cortisol [7]
The objective of this review is to find out the correlation of vitamin D levels with diabetic ketoacidosis so that vitamin D supplementation can become an integral part of diabetic ketoacidosis prevention and management
Summary
BackgroundVitamin D deficiency is prevalent around the globe, with an estimated one billion people being vitamin D deficient [1]. The relationship between vitamin D deficiency and type 1 and type 2 diabetes mellitus has long been established. Several studies on animals as well as on humans have supported the notion that both type 1 and type 2 diabetes mellitus are associated with vitamin D deficiency [2,3,4,5]. Diabetic ketoacidosis is a complication of uncontrolled type 1 diabetes mellitus, which results from insulin deficiency or excess of adrenaline or cortisol [7]. The objective of this review is to find out the correlation of vitamin D levels with diabetic ketoacidosis so that vitamin D supplementation can become an integral part of diabetic ketoacidosis prevention and management.
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