Abstract
Purpose. To investigate the correlation between best-corrected visual acuity (BCVA), the foveal inner segment/outer segment (IS/OS) junction or ellipsoid portion of inner segment (EPIS/ellipsoid zone), and the cone outer segment tips (COST) line or interdigitation zone integrity in eyes with uveitic macular edema (ME). Method. A retrospective observational study involving all patients from January 2012 to December 2013 with uveitic ME was performed. All patients underwent BCVA using Snellen charts spectral-domain optical coherence tomography (SD-OCT) examination using Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). Results. Fifty-two eyes from 45 patients were included in this study. Multivariate analysis showed a negative correlation between BCVA and the central retinal subfield thickness (CST), the cystoid pattern of edema, and the interdigitation zone interruption. Univariate logistic analysis showed a strong correlation between the ellipsoid zone and the interdigitation zone integrity. Conclusions. The ellipsoid zone defect, the interdigitation zone interruption, and the CST are correlated with poor vision. Visual acuity is also strongly affected by the cystoid pattern. The interdigitation zone integrity appears to be the most important factor in the visual prognosis of uveitic ME.
Highlights
Macular edema (ME) is a typical, but nonspecific, complication of uveitis and occurs most frequently in those with vitreous involvement
The purpose of the present study was to investigate the correlation between the best-corrected visual acuity (BCVA), the foveal EPIS, and interdigitation zone integrity in eyes with uveitic ME
This study showed the correlations between VA and the cystoid pattern of ME, central retinal subfield thickness (CST), EPIS, and interdigitation zone integrity in uveitic ME
Summary
Macular edema (ME) is a typical, but nonspecific, complication of uveitis and occurs most frequently in those with vitreous involvement. ME is among the leading causes of decreased vision in patients with uveitis [1, 2]. ME is described in intermediate uveitis (25–70%), anterior uveitis (20–26%), panuveitis (35%), and posterior uveitis (20%) and it can dramatically affect vision [3]. Optical coherence tomography (OCT) is a noncontact and noninvasive diagnostic technique, which is increasingly used for diagnosing macular pathology and evaluating the response to therapy [4,5,6,7]. OCT provides a fundamental contribution to the diagnosis, guidance, and treatment of retinal pathologies such as macular edema, macular holes, epiretinal membranes, central serous chorioretinopathy, and age-related macular degeneration [5, 6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
