Abstract
BackgroundThe common presence of human leukocyte antigen (HLA)-DRB1*04 in Vogt-Koyanagi-Harada (VKH) disease is well known. The aim of this study was to investigate the relationship between visual prognosis and HLA-DRB1*04 alleles during systemic corticosteroid therapy in patients with VKH disease.MethodsThis retrospective case series included 57 eyes from 29 consecutive patients with treatment-naïve VKH disease who received systemic corticosteroid therapy. Visual acuity, sex, refractive error, central retinal thickness (CRT), central choroidal thickness (CCT), and duration from onset to treatment were measured at initial and final visits. Mean values of parameters were compared with each visit. Genotyping was performed by polymerase chain reaction amplification with sequence-specific primer.ResultsLinear regression showed significant differences in logMAR best-corrected visual acuity between the three groups of homozygotes, heterozygotes, and normal subjects at baseline (p < 0.01), at 3 months after treatment (p < 0.01). There was no significant differences at 6 months after treatment (p = 0.257). No significant differences were detected between the three groups in age, sex, refractive error, CRT, CCT, or duration from onset to treatment.ConclusionAlleles of HLA-DRB1*04 might affect visual prognosis and be related to early response after initiation of treatment in VKH disease.
Highlights
The common presence of human leukocyte antigen (HLA)-DRB1*04 in Vogt-Koyanagi-Harada (VKH) disease is well known
The disease presents as acute bilateral granulomatous panuveitis, which responds to systemic corticosteroid therapy and generally shows good visual prognosis with relatively short follow-up [2]
The present study revealed a correlation between HLA04 allele and visual outcomes before and after initiating systemic corticosteroid therapy in treatment-naïve patients with VKH disease
Summary
The common presence of human leukocyte antigen (HLA)-DRB1*04 in Vogt-Koyanagi-Harada (VKH) disease is well known. The aim of this study was to investigate the relationship between visual prognosis and HLA-DRB1*04 alleles during systemic corticosteroid therapy in patients with VKH disease. Vogt-Koyanagi-Harada (VKH) disease is a systemic disorder that is considered to represent an autoimmune disease against melanocytes [1]. The disease presents as acute bilateral granulomatous panuveitis, which responds to systemic corticosteroid therapy and generally shows good visual prognosis with relatively short follow-up [2]. The human leukocyte antigen (HLA) system is the locus of Misawa et al BMC Ophthalmology (2019) 19:214 genes associated with increased risk of VKH to the identification of alternate genes [9, 10]. We report an investigation of correlations between HLA04 allele type and visual outcomes before and after steroid treatment in the real world
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
