Correlation between Uric Acid serum and Endothelin - 1 Plasma Levels in Hypertension with Hyperuricemia Patients in Dr. Mohammad Hoesin Hospital Palembang

Abstract

Hypertension and hyperuricemia are associated with cardiovascular risk. Hyperuricemia activated the renin-angiotensin-aldosterone system (SRAA) through activation of angiotensin - I to angiotensin - II, where the effect of the angiotensin - II will lead to increased pressure intraglomerular, macrophage activation and cytokine production, as well as vasoconstriction effect on blood vessels. This condition will increased endothelin - 1 (ET - 1), adhesion molecules, nuclear factor - kβ (NF - kβ), lower nitric oxide (NO) and nitric oxide synthase uncoupling and increase reactive oxygen species (ROS). Increased levels of ET - 1 is considered as one of the strongest independent factor associated with cardiovascular disease. The aim of this study was to know the correlation between uric acid serum and plasma ET-1 levels. This was a descriptive study conducted at the outpatient clinic and wards of Internal Medicine Department, dr. Mohammad Hoesin (RSMH) hospital Palembang from February to August 2014. The subjects were hypertensive patients with hyperuricemia. We collected 32 subjects, 53.1 % males and 46.9 % women. Mean uric acid was 7.85 ± 1,47 mg/dl and plasma ET - 1 levels was 1,555 (0,948–9,688). The correlation between uric acid and plasma ET – 1 level was significant, p value = 0.002, r = 0,499 and R square = 0,249. This study showed there was moderate correlation between serum uric acid and plasma ET-1 level.