Correlation between ultrasonographic features and expression of ER, PR, CerB-2, and Ki-67 in breast invasive ductal carcinoma

Abstract

Objective To explore the correlation between ultrasonographic features and the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (CerB-2), and Ki-67 in breast invasive ductal carcinoma (IDC). Methods The data of 189 IDC patients who were treated at our hospital from June 2015 to February 2019 were collected. Their ultrasonographic data and immunohistochemical pathologic results were analyzed. Results The positive rates of ER, PR, CerB-2, and Ki-67 in IDC were 63.4% (120/189), 52.9% (100/189), 45.5% (86/189), and 65.6% (124/189), respectively. The positive expression rates of ER and PR in patients with spiculation were significantly higher than those in patients without (70.0% vs. 56.2%, 60.0% vs. 44.9%, P<0.05). The positive expression rates of CerB-2 and Ki-67 in patients with microcalcification were significantly higher than those in patients without (53.4% vs. 38.8%, 73.2% vs. 59.2%, P<0.05). The positive expression rates of CerB-2 and Ki-67 in patients with rich blood flow signals were significantly higher than those in patients with poor blood flow signals (52.2% vs. 35.8%, 72.1% vs. 56.4%, P<0.05). The positive expression rate of CerB-2 in patients with suspicious positive lymph nodes was higher than that in patients without (54.3% vs. 34.8%, P<0.05). Conclusion There is a correlation between ultrasonographic features and the expression of ER, PR, CerB-2, and Ki-67 in IDC of the breast. The ultrasonographic features may provide more evidence for the diagnosis, clinical treatment, and prognosis of IDC of the breast. Key words: Breast invasive ductal carcinoma; Ultrasonographic; ER; PR; CerB-2; Ki-67