Correlation between TyG (Fasting Triglyceride-glucose) Index, TyG BMI Index & Liver Transaminases in Women with Polycystic Ovary Disease Syndrome

Abstract

Background: Polycystic Ovary Disease Syndrome (PCOS) and NAFLD are interlinked with the common culprit i.e. Insulin resistance (IR). The triglyceride and glucose index (TyG) has been recommended as a reliable and simple surrogate index for IR. So we evaluated TyG index, TyG–BMI index as a marker of IR and its correlation with liver transaminases (ALT, AST) to detect NAFLD in women with PCOS. Aim and Objectives: Correlation of TyG index and TyG-BMI index and liver transaminases (ALT, AST) in study groups. Materials and methods: A prospective study was done on 25 participants (14 controls and 11cases of PCOS according to Rotterdam’s criteria). The TG, FBG, ALT and AST were analyzed on autoanlyzers. TyG -BMI index was calculated by the formula and correlation was done. Result: The ROC Curve showed the optimal cut off value for TyG index as 4.55 and TyG –BMI index in PCOS as 104.76. The positive linear regression was 2.55 for TyG index indicating that test was associated with IR. TyG index has shown the better performance as compared to TyG BMI index. No significant correlation was found between TyG index, TyG BMI index and transaminases. Conclusion: TG and FBG are inexpensive and routinely performed investigations. TyG index which can be easily calculated makes it the first choice screening alternative to detect risk of IR in PCOS women. Keywords: PCOS, TyG -BMI index, Nonalcoholic fatty liver disease, liver transaminases