Correlation between Traditional Chinese Medicine Constitution and Dyslipidemia: A Systematic Review and Meta-Analysis.

Ye-Lin Ma,Hui Yao,Min-Chun Yang,Xuan-Xuan Ren,Wei-Jia Yang,Long Teng

doi:10.1155/2017/1896746

Abstract

Objective To study the correlation between Traditional Chinese Medicine (TCM) constitution and dyslipidemia. Methods CNKI, VIP, Wanfang database, CBMdisc, PubMed, and Embase were searched, and meta-analysis was performed by Review Manager 5.2 software. Results Altogether 11 studies were included with 12890 individuals. The results showed that balanced constitution was a protective factor of dyslipidemia (OR = 0.62, 95% CI 0.47~0.82) while phlegm-dampness constitution was a risk factor of it (OR = 2.50, 95% CI 2.22~2.80), and the effect of phlegm-dampness constitution in South China (OR = 3.31, 95% CI 1.71~6.43) was more obvious than that in East (OR = 2.40, 95% CI 2.06~2.80) and North China (OR = 2.24, 95% CI 1.81~2.78). Conclusion This study provides evidence for the prevention and treatment of dyslipidemia in TCM. However, most of the studies included are of moderate quality; more high quality, multicenter, large-sample studies are expected to provide higher level evidence.

Highlights

Dyslipidemia refers to the abnormal quantity and quality of lipids in plasma, most of which result from the interaction between genetic defects and environmental factors
A series of clinical studies based on the correlation between dyslipidemia and Traditional Chinese Medicine (TCM) constitution have been reported, which provide important clinical evidence for exploring the distribution of TCM constitution in dyslipidemia population, but there has been no systematic review or summary of the existing literature
Inclusion criteria are as follows: A research type: all clinical studies of correlation between TCM constitution and dyslipidemia, any nationality, written in Chinese or English; B disease diagnosis: the research objects were definitely diagnosed as dyslipidemia; C constitution identification: constitution was identified by “Classification and determination of TCM constitution” [14] criteria published by China Association of Chinese Medicine (CACM) in 2009; D research results: the distribution of TCM constitution in dyslipidemia and ortholiposis population were both reported

Summary

Objective

To study the correlation between Traditional Chinese Medicine (TCM) constitution and dyslipidemia. 11 studies were included with 12890 individuals. The results showed that balanced constitution was a protective factor of dyslipidemia (OR = 0.62, 95% CI 0.47∼0.82) while phlegm-dampness constitution was a risk factor of it (OR = 2.50, 95% CI 2.22∼2.80), and the effect of phlegm-dampness constitution in South China (OR = 3.31, 95% CI 1.71∼6.43) was more obvious than that in East (OR = 2.40, 95% CI 2.06∼2.80) and North China (OR = 2.24, 95% CI 1.81∼2.78). This study provides evidence for the prevention and treatment of dyslipidemia in TCM. Most of the studies included are of moderate quality; more high quality, multicenter, large-sample studies are expected to provide higher level evidence

Introduction

Materials and Methods

Results

Discussion

Conflicts of Interest