Correlation between thyroid hormones and body weight in hypothyroid females in Erbil city

Abstract

Hypothyroidism, also known as underactive thyroid, is a condition where the thyroid gland does not produce enough of thyroid hormone called thyroxine. Thyroid hormones regulate the way in which the body uses energy - metabolism - and without enough thyroxine, many of the body's functions slow down. Through this study we aim to define any relationship of fluctuations that might exist between serum thyroid stimulating hormone, triiodothyronine and its prohormone thyroxine with body weight in hypothyroidism under thyroxin therapy. The present cross-sectional study deals with estimation of levels of serum thyroid stimulating hormone, triiodothyronine, thyroxine, Vitamin D 3 and calcium in (100) patients with hypothyroidism, all the biochemical parameters were estimated calorimetrically. The mean ± SE concentrations of serum thyroid stimulating hormone, triiodothyronine, thyroxine, Vitamin D and Calcium were 33.6 ± 1.3 UIU/ml, 10.6 ±1.1 nmole/L, 41.1 ±1.4 nmole/L, 29.5 ± 2.3 nmole/L and 13.4 ± 2.1 mg/dl, respectively. In the existing study we found, a statistical positive correlation (r = 0.404 ) between thyroid stimulating hormone and body weight. While there were a negative correlation between triiodothyronine (r = -0,41538 ), thyroxine (r = -0,41538 ) and body weight. Our results of the present study demonstrates that weight gain and obesity are two common manifestation of hypothyroidism.