Abstract
A quantitative ultrastructural investigation of mouse mammary gland carcinoma and of its metastases in the lungs was undertaken. The surface area of the membranes of the endoplasmic reticulum and the number of bound ribosomes were found to be greater in tumors not giving rise to metastases than in tumors giving metastases in the experiments. Meanwhile the number of ribosomes combined into polysomes was greater in metastasizing tumors. Comparison of the tumors and their metastases revealed differences in the structure of the mitochondrial apparatus: The surface area of the mitochondrial cristae was greater in metastatic tumors. The results indicate that spreading metastases have a lower level of cell differentiation. Primary and metastatic foci are indistinguishable in their level in cell differentiation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
