Abstract
Studies comparing the negative inotropic effect of calcium antagonists and “related” receptor-affinities showed inconsistent results. We tested the possible relationship between the potency in inhibiting CaCl2-induced positive inotropy and receptor affinity. Therefore, we determined the relative potency of Nifedipine, Verapamil, Fendiline, Bepridil and Diltiazem both in isolated rabbit papillary muscle against CaCl2-induced positive inotropy (pA2) and their relative affinity (-log KD) in receptor binding experiments in rat cardiac homogenates.
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