CORRELATION BETWEEN THE PREOPERATIVE SERUM PROSTATE SPECIFIC ANTIGEN, GLEASON SCORE AND STAGING USING MRI WITH POSTOPERATIVEHISTOPATHOLOGICAL OUTCOME FOLLOWING ROBOT ASSISTED RADICAL PROSTATECTOMY.

Abstract

Introduction: Prostate cancer is second most common cancer in Indian men1. Early detection may be the cause of this increasing trend in urban areas. In our study, we have tried to study correlation between preoperative serum PSA, Gleason score and staging using MRI with postoperative histopathological outcome following robot assisted radical prostatectomy (RARP). Objectives of the study: To correlate between preoperative PSA, Gleason score, and staging with MP-MRI with pathological outcome following RARP in men with clinically localized cancer prostate and assess accuracy of preoperative Gleason score and staging with MRI with post operative histopathology. Materials and Methods:Asingle center, hospital based prospective observational study of 87 patients with age > 50 years with localized prostate cancer was conducted in department of urology at tertiary care center for study period between November 2019 to November 2021. Data collected from these patients' included demographic, clinical history, physical ndings, detailed investigations, operative details, postoperative ndings and results were analyzed. Results:Atotal of 87 localized carcinoma prostate patients were enrolled into the study. It was found that in nal histopathology report post RARP, organ conned disease was seen in 52 (59.77%) patients, capsular involvement in 35(40.22%), seminal vesicle invasion seen in 14(16%) and 2 (0.25%) had positive lymph node involvement. On correlating serum PSA, biopsy Gleason score and staging with MRI with postoperative pathology, it was found that in localized carcinoma prostate on MRI with higher serum PSA, raised Gleason score and higher stage, organ conned disease decreases linearly with signicant P value of (0.005), (0.005), (0.007). Conclusion: Based on data of our study we conclude that patients with localized prostate cancer on MRI, if they have higher preoperative serum PSA, higher Gleason score, and higher stage, then they have more chances of locally advanced disease on postoperative histopathology