Correlation between the Nonperfusion Area on Ultra-Widefield Fluorescein Angiography and Nonflow Area on Optical Coherence Tomographic Angiography in Retinal Vein Occlusion.

Jianfeng Huang,Bodi Zheng,Xiaoya Gu,Yingyi Lu,Tong Chen,Masaru Takeuchi

doi:10.1155/2021/5581319

Abstract

Aims To compare the relationship between the nonperfusion area (NPA) on ultra-widefield fluorescein angiography (UWFFA) and the nonflow area (NFA) on optical coherence tomographic angiography (OCTA) in retinal vein occlusion (RVO). Methods Cross-sectional study. 46 eyes of 46 RVO patients who underwent UWFFA and OCTA. NPA and ischemic index (ISI) were quantified on UWWFA. NFA, vessel density (VD) of the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and the size foveal avascular zone (FAZ) on 3 ∗ 3 mm OCTA were measured. The association of the NPA and ISI on UWWFA and the parameters on OCTA were analyzed. Spearman correlation was used for statistical testing. Results The NPA and ISI on UWFFA were significantly correlated with the NFA on OCTA in RVO, and r values were 0.688 (p < 0.01) and 0.680 (p < 0.01), respectively. VD in the SCP of the temporal quadrant was negatively correlated with NPA and ISI, and r values were −0.346 (p < 0.05) and −0.337 (p < 0.05), respectively. VD in the DCP of the temporal quadrant was negatively correlated with the NPA, and the r value was −0.246 (p < 0.05). No significant correlation was found between the NPA and ISI on UWFFA and VD of other quadrants in the SCP or DCP and the FAZ area on OCTA. Conclusion NPA in the peripheral retina was correlated with NFA in macula. NFA detected by OCTA could be an indicator of the ischemic status in RVO.

Highlights

Retinal vein occlusion (RVO) is among the most common type of retinal vascular diseases [1]
The field of view of ordinary optical coherence tomographic angiography (OCTA) is smaller than the widefield one, we considered whether the NP area detected by UWFA is correlated to the nonflow area detected by ordinary 3 ∗ 3 mm OCTA
We found that the nonflow area on the 3 ∗ 3 mm OCTA macular image was positively strongly correlated with the NP area and ischemic index (ISI) on the UWFA image in RVO, which indicated that the ischemic status of the central retina can be a reflection of the status of the peripheral retina

Summary

Introduction

Retinal vein occlusion (RVO) is among the most common type of retinal vascular diseases [1]. RVO can lead to an impairment of blood circulation and retinal ischemia. Extensive peripheral ischemia can lead to retinal neovascularization [2], which can cause vitreous hemorrhage and vision loss. Studies have shown the use of ischemic index (ISI), a ratio of nonperfused retina to total visible retina, as an important assessment in evaluating the ischemic status in retinal vascular diseases including RVO and diabetic retinopathy (DR) [3,4,5]. FA is an invasive examination and is unrepeatable on the same day or in the short term. It can cause severe complications such as anaphylaxis, cardiac arrest, and bronchospasm [7]. A noninvasive, safe, and easy-tomanipulate measurement should be developed to evaluate the ischemic status of the retina, or this noninvasive measurement can be used as a predictive factor for a necessary FA

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Results

Conclusion