Correlation between the main indicators of organ donation and donor liver and the early prognosis of transplant after the death of citizens

Abstract

Objective To explore the correlation between main indicators of donor liver and early prognosis after liver transplantation. Methods The clinical data of 166 donors and recipients of post-mortem organ donation (DD) from June 2017 to June 2018 were retrospectively analyzed.The effects of donor age, sex, body mass index, serum sodium level, total bilirubin, prothrombin time and international standardized ratio on early allograft dysfunction (EAD) in liver transplant recipients were investigated.According to the culture results of donor liver preservation solution, the results were divided into positive group and negative group.Combined with the culture results of blood, sputum and drainage fluid after liver transplantation, the early infection rate of recipients in the two groups was observed. Results Univariate analysis showed that preoperative donor bilirubin total >17.1 mmol/L and donor cold ischemia time >8 h were risk factors for postoperative EAD in transplant recipients.Multivariate analysis showed that donor cold ischemia time >8 h was an independent risk factor for postoperative EAD in liver transplant recipients; the incidence of EAD in the group with cold ischemia time >8 h was significantly higher than that in the group with cold ischemia time ≤8 h (26.3% vs.7.0%; P=0.003). The positive rate of postoperative sputum culture and drainage fluid culture in the donors with positive donor culture was 43.9% and 48.8%, respectively, which was significantly higher than that in the negative group (10.7% and 13.1%). The difference was statistically significant (P=0.000, P=0.000). The positive rate of postoperative blood culture in the positive group and the negative group was 12.2% and 6.0% with the difference being not statistically significant (P=0.161). Conclusion Cold ischemia time of the donor >8 h is an independent risk factor for EAD in recipients after liver transplantation.Shortening the cold ischemia time of donor liver can reduce the incidence of postoperative EAD in recipients.The culture results of preservation solution have a certain guiding effect on the postoperative anti-infective treatment of the recipients. Key words: Liver transplantation; Evaluation; Early allograft dysfunction; Cold ischemia time