Correlation between the histopathological findings of gallbladder samples and clinical outcomes within the framework of a hybrid study

Abstract

Background: This study focuses on the histopathological characteristics of benign and potentially malignant lesions of the gallbladder, with a specific emphasis on the efficacy of cholecystectomy as a secondary preventive measure in specific clinical contexts. The aim is to contribute to the development of improved preventive and therapeutic approaches. Methodology: This research study employed a hybrid approach of retrospective and prospective data analysis on cholecystitis during the year 2023. Various variables were analyzed to explore their associations with clinical outcomes. Results: The study included 63 patients, with no statistically significant differences in age between male and female patients. Analysis of the length, width, and thickness of the gallbladder wall did not reveal statistically significant differences (p > 0.05). Correlation analysis showed weak connections between age and gallbladder characteristics. The average recovery time was 4.46 days, and the duration of hospitalization positively correlated with age (p<0.001). Regression analysis indicated an association between symptoms and age and the duration of hospitalization (p = 0.015, p<0.001). Logistic regression demonstrated an accuracy of 61.9%, with high precision in predicting stays longer than 3 days. Chi-square tests confirmed statistically significant differences in histopathological diagnoses related to comorbidities (p = 0.021). Conclusion: Gender-specific approaches in postoperative treatment of patients with gallbladder issues highlight significant differences in patient characteristics, while the analysis of comorbidities reveals a connection between hypertension and pathological changes in the gallbladder.