Abstract
The infection of Helicobacter pylori (H. pylori) is one of the most important causes of gastric ulcer disease. The role of hydrogen sulfide (H2S) production in H. pylori-induced gastric ulcer disease. The expression of cystathionine-γ-lyase (CSE) was determined, and correlated with the severity of gastric ulcer disease. One hundred and eight patients were selected based on the determination of gastric ulcer and the infection of Helicobacter pylori (H. pylori), including 36 normal control, 36 patients with H. Pylori-negative gastric ulcer, and 36 patients with H. Pylori-positive gastric ulcer. RT-PCR determination was performed to determine the expression of CSE, NF-κB and IL-8. The expression of CSE, NF-κB and IL-8 was higher in the gastric ulcer group than control group (p<0.05). Compared with the H. pylori-negative gastric ulcer, the expression of CSE, NF-κB and IL-8 was higher than H. pylori-positive gastric ulcer group (p<0.05). For H. pylori-negative gastric ulcer group, the expression of CSE positively correlated with the expression of NF-κB (r=0.98, p<0.05) and IL-8 (r=0.95, p<0.05). For H. pylori-positive gastric ulcer group, the expression of CSE also positively correlated with the expression of NF-κB (r=0.99, p<0.05) and IL-8 (r=0.85, p<0.05). The expression of CSE was positively correlated with the severity of gastric ulcer.
Highlights
Many factors contributed to the pathogenesis of peptic ulcer disease, including the utilization of NASIDs and smoking
Hydrogen sulfide (H2S) has been demonstrated to exhibit protective role in damage of gastric mucosa induced by NSAIDs, acetate, ethanol . 9-13 CBS and CSE are two key enzymes involved in the synthesis of H2S, and the activity of these two enzymes can reflect the level of H2S
Previous literatures have shown that H.pylori adhered to the surface of gastric mucosa and resulted in the secretion of antigens which damage the integrity of epidermal cells located in stomach
Summary
Many factors contributed to the pathogenesis of peptic ulcer disease, including the utilization of NASIDs and smoking. The infection of Helicobacter pylori (H. pylori) is one of the most important causes of peptic ulcer disease. Helicobacter pylori infects the gastric mucosa and induces chronic active inflammation which affects on gastric acid secretion in a variable and complex manner1 During this process, some cytokines (IL-1, IL-6, and IL-8) and chemokines were significantly increased, and nuclear factor kappa B (NF-κB) was activated 2-5. The infection of Helicobacter pylori (H. pylori) is one of the most important causes of gastric ulcer disease. The role of hydrogen sulfide (H2S) production in H. pylori-induced gastric ulcer disease. Aim:The expression of cystathionine-γ-lyase (CSE) was determined, and correlated with the severity of gastric ulcer disease. For H.pylori-negative gastric ulcer group, the expression of CSE positively correlated with the expression of NF-κB (r=0.98, p
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