Abstract
Background Diabetes is up to four times more common in HIV-infected individuals exposed to antiretroviral therapy. Haematological parameters are important indicators for the assessment and management of patients with diabetes. The aim of this study was to determine the correlations between biochemical and haematological parameters in type 2 diabetic patients living with HIV. Methods A total of 260 participants consisting of 100 HIV-positive and 160 HIV-negative diabetics. Blood samples were obtained from fasting subjects by venipuncture at the elbow. They were used to obtain plasma and serum after centrifugation at 3000 rpm for 15 minutes. Creatinine, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, C-reactive protein, magnesium, phosphorus, urea, uric acid and cystatin C, glycated haemoglobin, blood glucose and blood count were measured. Results The correlation between the biochemical and haematological profile showed that blood glucose correlated positively with white blood cell count (r=0.204, p=0.042), red blood cell count (r=0.216, p=0.031), neutrophil count (r=0.265, p=0.008), basophil count (r=0.229, p=0.022), monocyte count (r=0.271, p=0.006) and lymphocyte count (r=0.205, p=0.041). This correlation was negative for mean blood volume (r=-0.202, p=0.043). Phosphorus was negatively correlated with mean corpuscular haemoglobin concentration (r=-0.245, p=0.014) and monocyte count (r=-0.24, p=0.016), but positively correlated with eosinophil count (r=0.256, p=0.010). Conclusion Disturbances in the biochemical and haematological profiles were observed in diabetics living with HIV. The correlations found in these two associated chronic pathologies showed the link of blood glucose with many of haematological parameters.
Highlights
Diabetes is becoming a major health problem in Africa
The correlation between the biochemical and haematological profile showed that blood glucose correlated positively with white blood cell count (r=0.204, p=0.042), red blood cell count (r=0.216, p=0.031), neutrophil count (r=0.265, p=0.008), basophil count (r=0.229, p=0.022), monocyte count (r=0.271, p=0.006)
Disturbances in the biochemical and haematological profiles were observed in diabetics living with HIV
Summary
Diabetes is becoming a major health problem in Africa. Africa is experiencing a growing prevalence of diabetes as is the case with other non5708 communicable diseases [2]. Several infectious diseases such as HIV are very present in sub-Saharan Africa with 25.7 million people living with HIV [3] and its corollaries of coinfection or association with non-communicable diseases such as diabetes, hypertension. Diabetes is up to four times more common in HIV-infected individuals exposed to antiretroviral therapy. Haematological parameters are important indicators for the assessment and management of patients with diabetes. The aim of this study was to determine the correlations between biochemical and haematological parameters in type 2 diabetic patients living with HIV
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Medical Science and Clinical Invention
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
