Abstract
Introduction: Oxidative stress on tissues can cause diseases such as diabetes mellitus (DM). Aim: This study aimed to pharmacologically evaluate the decrease in blood glucose levels and its relationship with the total antioxidant capacity of the blood compared to glibenclamide. Method: An experimental study with completely randomised designs was carried out. Rats were induced with streptozotosin followed by ethanolic extract for ten days. Results: The One-Way Anova test, showed that the increase of the total antioxidant capacity of plasma treated with ethanolic extract of Tinospora cordifolia and Curcuma zanthorrhiza was comparable in the same amount to glibenclamide (p=0.345), (p=0.289). There was a relationship between total blood antioxidant capacity and blood glucose levels, this linear association was expressed with the following mathematical equation: y = 20,253 - 2,946x. Conclusion: The antioxidant content of Tinospora cordifolia, Curcuma zanthorrhiza, and Cinnamomum verum has the potential to control blood glucose in diabetes mellitus.
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