Abstract
BackgroundRecently, the AMADEUS (Area Measurement And DEpth Underlying Structures) grading system has been introduced to evaluate and grade osteochondral lesions prior to cartilage surgery. The AMADEUS score has not been connected to clinical data in order to test a potential clincial impact.PurposeTo examine the correlation between the AMADEUS score and preoperative patient-reported outcome measurements (PROMs).Study designCase seriesMethodsPatients treated with matrix-induced autologous chondrocyte implantation (MACI) were included in the study, unless exclusion criteria like BMI > 35, prior extensive meniscectomy or ongoing inflammatory arthritis were present. Preoperative magnetic resonance (MR) examinations were graded according to the standardized AMADEUS protocol. The final AMADEUS score was correlated with preoperative patient-reported outcome measurements (PROMs), including the IKDC (International Knee Documentation Committee), the Lysholm score, the Short-Form-12 (SF-12) score, and the Core Outcome Measures Index (COMI) score.ResultsA total of 50 patients with a mean age of 33.6 ± 11.5 years, a mean BMI of 25.1 ± 4.9, and a mean defect size of 2.3 ± 1.5 cm2 were included in the study. More severe cartilage defects, indicated by the AMADEUS grade (R = 0.35, p = 0.01) and the AMADEUS score (R = − 0.36, p = 0.01) as well as larger chondral defects (R = 0.32, p = 0.03) show a moderate correlation with the higher COMI scores. No correlative capacity was demonstrated for the AMADEUS score and the IKDC, Lysholm, and Tegner activity scores as well as for its subscales.ConclusionThere is a moderate correlation of the COMI and the AMADEUS score in patients treated with matrix-induced autologous chondrocyte implantation (MACI). All other patient-reported outcome measurement scores (PROMs) show no evidence of an association to the magnetic resonance-based AMADEUS score.Clinical relevanceThe clinical and scientific implication of the COMI score as a PROM tool can be recommended when working with the AMADEUS score and patients undergoing MACI.
Highlights
Matrix-induced autologous chondrocyte implantation (MACI) has become an important and widely used treatment option for large, full-thickness chondral defects of the knee [1, 2]
There is a moderate correlation of the Core Outcome Measures Index (COMI) and the Area Measurement And DEpth Underlying Structures (AMADEUS) score in patients treated with matrixinduced autologous chondrocyte implantation (MACI)
Clinical relevance: The clinical and scientific implication of the COMI score as a patient-reported outcome measurements (PROMs) tool can be recommended when working with the AMADEUS score and patients undergoing MACI
Summary
Matrix-induced autologous chondrocyte implantation (MACI) has become an important and widely used treatment option for large, full-thickness chondral defects of the knee [1, 2] This has created the need and desire for reliable radiological classification and outcome tools for chondral lesions both pre- and postoperatively. The AMADEUS (Area Measurement And DEpth Underlying Structures) grading system has been introduced. This magnetic resonance (MR)-based classification system was developed in order to evaluate and grade osteochondral lesions prior to cartilage surgery [5]. The AMADEUS (Area Measurement And DEpth Underlying Structures) grading system has been introduced to evaluate and grade osteochondral lesions prior to cartilage surgery. Purpose: To examine the correlation between the AMADEUS score and preoperative patient-reported outcome measurements (PROMs)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
