Correlation between the abnormal thyroid function in first trimester and the gestational hypertension disease

Abstract

Objective To investigate the correlation between abnormal thyroid function in first trimester and gestational hypertension. Methods A total of 1 176 cases of single pregnant women in Jiaozuo Maternal and Child Health Hospital from January 2015 to October 2016 were allocated into study. And they were divided into gestational hypertension group (77 cases), preeclampsia group (49 cases) and control group (1 050 cases) according to the pregnancy outcomes. The general condition of all pregnant women were recorded and the thyroid function results in the first trimester were recorded. Results Logistic regression analysis showed that subclinical hypothyroidism had obvious correlation with the occurrence of gestational hypertension(OR=4.1, 95%CI=1.30-13.20, P=0.016), and subclinical hypothyroidism was significantly correlated with the occurrence of preeclampsia (OR=5.7, 95%CI=1.51-21.30, P=0.010). Conclusions Abnormal thyroid function in first trimester is closely related to gestational hypertensive. Key words: Thyroid function; Gestational hypertension; Thyroid-stimulating hormone; Free thyroxine