Correlation between serum vitamin D level and arterial stiffness in elderly patients with impaired renal function

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Objective To investigate the relationship between serum level of 25-hydroxyvitamin D and arterial stiffness in elderly patients with impaired renal function. Methods A cross-sectional study was conducted. Serum creatinine and 25-hydroxyvitamin D levels in elderly patients aged 60 years and over were detected at admission. The estimated glomerular filtration rate (eGFR) was calculated. Patients were divided into 2 groups of the normal eGFR (≥60 ml/min) group and the impaired eGFR (<60 ml/min) group. Carotid-femoral pulse wave velocity (cfPWV) was used to assess the arterial stiffness. The differences in serum 25-hydroxyvitamin D levels and arterial stiffness were compared between the two groups. Results A total of 256 patients were enrolled in this study. The mean(SD) age at admission was (74.5±9.4) years, with a range of 60~92 years, 172 males and 84 females. There were 143 cases in the normal eGFR group (control) and 113 cases in the impaired eGFR group. No differences in baseline clinical data including age, gender, body mass index, blood lipids, etc. were found between the two groups. Compared with the control group, serum 25-hydroxyvitamin D level was decreased and cfPWV was increased in the impaired eGFR group 〔(12.31 ±9.56)μg/L vs. (20.76 ± 12.97)μg/L, (15.1 ± 3.8) m/s vs. (12.9 ± 2.9) m/s, both P<0.05〕. Multiple liner regression analysis showed that serum 25-hydroxyvitamin D level was negatively associated with cfPWV (r=-0.59, P<0.05) after adjusting for age, gender and other confounders. Conclusions Serum vitamin D level is decreased and the arterial stiffness is increased in elderly patients with impaired renal function. Key words: Kidney function tests; Vitamin D; Arteriosclerosis