Abstract
Background & Objectives: Hyperuricemia occurs frequently in patients with myeloproliferative and lymphoproliferative disorders and in patients with congenital heart disease associated with polycythemia. Since it has been confirmed that serum uric acid levels have a relationship with severity and prognosis of disease, this study was done to evaluate the correlation between serum uric acid level and severity of pulmonary hypertension (PHT). Materials and Methods: This cross sectional study was done on 97 hospitalized children (mean age 48.9 months, range 3mo-15yrs) with congenital heart disease that underwent cardiac catheterization at the Aliasghar hospital between March 2001 and June 2002. The patients were divided into 2 groups: 42 cases with pulmonary hypertension, and 55cases with normal pulmonary artery pressure (NPAP). Results: Mean (SD) pulmonary arterial pressure in PHT and NPAP groups were 42.83mmHg (13.08) and 14.89mmHg (3.52), respectively (t=11.18, P<0.001). Mean (SD) serum uric acid levels in PHT and NPAP groups were 4.86mg/dl (2.27) and 4.46mg/dl (l.60), respectively (t=1.01, P=0.31). Mean (SD) ratio of pulmonary vascular resistance to systemic vascular resistance (Rp/Rs) in PHT and NPAP groups were 0.36 (0.18) and 0.11 (0.04), respectively. There was no relationship between serum uric acid levels and pulmonary mean arterial pressure (r=0.03, P<0.81), age (r=0.03, P<0.80), or Hemoglobin (r=0.26, P<0.1). Discussion: Increased serum uric acid levels had a direct correlation with pulmonary vascular resistance (r=0.40, P<0.009). We can use this correlation for prediction of severity and progression of disease to Eisenmenger syndrome.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.