Correlation Between Serum Uric Acid and Body Fat Distribution in Patients With Polycystic Ovary Syndrome.

Yuqin Zhang,Xiaowen Shao,Meili Cai,Shen Qu,Xinxin Gao,Hongxiang Fei,Ziwei Lin,Hang Sun,Qiongjing Zeng,Diliqingna Dilimulati,Ran Cui,Manna Zhang

doi:10.3389/fendo.2021.782808

Yuqin Zhang, Xiaowen Shao + Show 10 more

Open Access

https://doi.org/10.3389/fendo.2021.782808

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Abstract

ObjectiveThis study aims to investigate the correlation between serum uric acid levels and body fat distribution in patients with polycystic ovary syndrome (PCOS).MethodsBetween May 2017 and March 2021, a total of 199 patients with PCOS were recruited from the Department of Endocrinology and Metabolism at the Shanghai Tenth People’s Hospital. Anthropometric characteristics, metabolic parameters, and reproductive hormones were measured. Hyperuricemia was defined as serum uric acid (SUA) greater than 420 μmol/l. Dual-energy X-ray absorptiometry (DEXA) was used to measure body fat distribution.ResultsThe prevalence of hyperuricemia in patients with PCOS was 28.64%. PCOS patients with hyperuricemia are more obese and have a higher waist-to-hip ratio (WHR) and worse lipid metabolism than those without hyperuricemia. According to SUA quartiles, patients in the highest quartile had higher total testosterone (TT), body fat accumulation, and lower sex hormone-binding globulin (SHBG) than patients in the lowest quartile. SUA was correlated with percentage of total body fat, arm fat mass, leg fat mass, trunk fat mass, android/gynoid (A/G) ratio, and visceral adipose tissue (VAT) mass. After controlling possible confounders, logistic regression analysis found that only excessive VAT mass could significantly increase the risk of hyperuricemia in patients with PCOS.ConclusionIn patients with PCOS, a high level of VAT mass, but not other fat compartments, will exacerbate the risk of hyperuricemia. Attention should be paid to the role of excessive VAT in the occurrence and development of PCOS with hyperuricemia.

Highlights

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in women of normal reproductive age, which is characterized by clinical and/or biochemical signs of androgen excess, ovulatory dysfunction, and polycystic ovarian morphology [1]
The mean HOMA-IR, PPG, FINS, F-CP, ALT, AST, serum uric acid (SUA), HDL-c, SHBG, and the rate of metabolic syndrome were significantly different among the three groups
After adjustment for age (Model 1), we found that the higher levels of percentage of total body fat, trunk fat mass, android fat mass, gynoid fat mass, visceral adipose tissue (VAT) mass, and abdominal subcutaneous adipose tissue (SAT) mass will increase the risk of hyperuricemia in PCOS patients

Summary

Introduction

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in women of normal reproductive age, which is characterized by clinical and/or biochemical signs of androgen excess, ovulatory dysfunction, and polycystic ovarian morphology [1]. Previous observational studies have shown that the serum uric acid (SUA) levels and the prevalence of hyperuricemia were significantly higher in patients with PCOS than in patients without PCOS [4,5,6,7]. In some populations other than PCOS patients, such as healthy people, diabetic patients, and obese people, many scholars have conducted research on the relationship between uric acid or hyperuricemia and adiposity/ body fat distribution [10,11,12,13,14,15,16,17]. As far as we know, there are few epidemiological studies evaluating the relationship between uric acid or hyperuricemia and body fat distribution in patients with PCOS

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