Abstract

Inflammatory mediators may reflect a role of systemic inflammation in the neurodegenerative process of Parkinson's disease (PD). Interleukin-6 (IL-6) and chemokine ligand 5 (CCL5), also known as RANTES (regulated on activation, normal T cell expressed and secreted), have been implicated in neurodegenerative diseases including PD. Serum levels of RANTES and IL-6 of 78 consecutive PD patients and age-matched 80 controls were measured. Patients with PD had higher RANTES and IL-6 levels compared with the controls. We found that serum RANTES levels strongly correlated with Hoehn-Yahr score and disease duration in PD patients. This study indicated that patients with PD have an on-going systemic inflammatory profile where the elevated peripheral production of RANTES may play a role in the neurodegenerative process.

Highlights

  • Parkinson’s disease (PD), a common neurodegenerative disease among the elderly, is characterized by resting tremor, slowness of movement, rigidity, and postural instability

  • Evidences have shown that RANTES and its receptor CCR5 play a role in a wide array of pathological conditions with neurodegenerative diseases such as PD, Alzheimer’s disease (AD), multiple sclerosis, stroke, and HIV-associated dementia [7,8,9]

  • The serum RANTES and IL-6 levels showed no significant difference between subgroups of PD patients treated and not treated with antiparkinson drugs (Table 2)

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Summary

Introduction

Parkinson’s disease (PD), a common neurodegenerative disease among the elderly, is characterized by resting tremor, slowness of movement, rigidity, and postural instability. A study reported that circulating level of IL-6 was elevated in the PD patients on average 4.3 years before the diagnosis, suggesting that the inflammation state was not limited in the local central region but expanded to the peripheral ones [5]. Another proinflammatory chemokine RANTES (known as regulated on activation, normal T cell expressed and secreted) has been implicated in the recruitment of immune cells, fundamental regulation of immunoreactions, and the maintenance of inflammatory states [6]. We investigated the relationship between RANTES, IL-6 levels, and the severity of the disease in PD patients, intending to describe the peripheral inflammatory profiles of PD patients

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