Abstract
Correlation between serum neopterin level and carotid artery intima- media thickness in type 2 diabetic patients
Highlights
Atherosclerosis is currently viewed as an immune-mediate inflammatory disease of the arterial wall, macrophages play an important role in atherogenesis.Inflammatory mechanisms with atherosclerotic plaque formation can be triggered,maintained and enhanced by multiple factors such as activated macrophages that induce synthesis of neopterin.The aim of the study: To evaluate the association between serum neopterin level and carotid atherosclerosis in type 2 diabetic patient and to highlight the role of inflammation in atherosclerosis and atherosclerotic cardiovascular disease
Serum neopterin is a marker of both macrophage activation and redox system activation and could be used as a potential biomarker in risk stratification while assessing and managing atherosclerotic cardiovascular diseases
Atherosclerosis is the focal expression of a systemic disease affecting medium- and large-sized arteries, in which traditional cardiovascular risk factor and immune factors play a key role
Summary
Atherosclerosis is currently viewed as an immune-mediate inflammatory disease of the arterial wall, macrophages play an important role in atherogenesis.Inflammatory mechanisms with atherosclerotic plaque formation can be triggered,maintained and enhanced by multiple factors such as activated macrophages that induce synthesis of neopterin.The aim of the study: To evaluate the association between serum neopterin level and carotid atherosclerosis in type 2 diabetic patient and to highlight the role of inflammation in atherosclerosis and atherosclerotic cardiovascular disease.
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