Abstract
Acute heart failure (AHF) occurs mostly in the elderly, which is a syndrome that occurs in the later stages of the development of cardiovascular disease. Due to the sharp decline in the patient's heart function, the patient has a high mortality rate and a poor prognosis, which seriously threaten the life safety of the elderly. Therefore, early diagnosis of AHF and timely treatment are extremely important. Lipoprotein-associated phospholipase A2 (LP-PLA2) is a newly discovered cardiovascular-specific inflammatory marker, which is closely related to the formation and progression of atherosclerotic plaque and the occurrence and development of coronary heart disease. Soluble growth stimulation expression gene 2 (sST2) protein is a protein produced under the induction of mechanical stress in cardiomyocytes. It can act as a decoy receptor to mediate the interleukin-33 (IL-33)/ST2 signaling pathway to bind to IL-33, thereby reducing the myocardial protective effect and leading to myocardial remodeling. The purpose of this study was to explore the serum LP-PLA2 and sST2 levels in AHF patients and to analyze their correlation with the disease and their prognostic value. The results showed that the levels of serum LP-PLA2 and sST2 were increased in AHF patients, and the levels of serum LP-PLA2 and sST2 in patients with adverse prognostic events were higher than those in patients without adverse prognostic events. The levels of serum LP-PLA2 and sST2 are closely related to the degree of patients' illness, among which the combined prediction of AHF patients with LP-PLA2 and sST2 has the highest value, which is worthy of promotion.
Highlights
Acute heart failure (AHF) refers to the acute onset or aggravated left heart dysfunction that leads to reduced myocardial contractility and increased heart load, resulting in increased pulmonary circulation pressure, leading to syndromes such as pulmonary circulatory congestion and cardiogenic shock [1, 2]
Lipoprotein-associated phospholipase A2 (LPPLA2) is a newly discovered cardiovascular-specific inflammatory marker, which is closely related to the formation and progression of atherosclerotic plaque and the occurrence and development of coronary heart disease [5, 6]
Researchers have found that brain natriuretic peptide (BNP), NT-pro BNP, and other important diagnostic biochemical markers of heart failure are restricted by age, sex, liver and kidney dysfunction, and other factors, resulting in the interference of the test results
Summary
Acute heart failure (AHF) refers to the acute onset or aggravated left heart dysfunction that leads to reduced myocardial contractility and increased heart load, resulting in increased pulmonary circulation pressure, leading to syndromes such as pulmonary circulatory congestion and cardiogenic shock [1, 2]. LPPLA2 mainly exists in the form of binding with lipoprotein particles, forming oxidized free fatty acids and lysophospholipid choline through hydrolysis of oxidized phospholipids, activating the expression of various inflammatory factors, participating in the body’s inflammatory response, and promoting the formation and progression of plaque. It plays a decisive role in the formation and progression of atherosclerosis and leads to plaque rupture and cardiovascular events [7, 8]. LP-PLA2 is an independent predictor of cardiovascular events It can hydrolyze plateletactivating factor and lose its activity, reduce the body’s
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