Correlation between serum heat shock protein 27 and soluble glycoprotein 130 levels in patients with chronic heart failure and short-term prognosis

Abstract

Objective To explore clinical short-term prognostic value of heat shock protein 27(HSP27)and soluble glycoprotein 130(Sgp130)on chronic heart failure(CHF). Methods From January 2014 to January 2016, 116 patients with CHF in Renmin Hospital of Wuhan University were enrolled in this study.They were followed up for 6 months.According to major adverse cardiac events(MACE)outcome, the patients were divided into non-MACE group(83 cases)and MACE group(33 cases). Logistic regression analysis was used to analyze the risk factors of MACE. Results Compared with non-MACE group, diabetes, dilated cardiomyopathy, NYHA classification, LVEF, LVEDD, LVESD, E/A, HSP27 and Sgp130 showed significant difference(all P<0.05). Logistic regression analysis showed that risk factors of MACE included NYHA classification(OR: 5.283, 95%CI: 2.861-9.460, P=0.003), LVEF(OR: 1.647, 95%CI: 1.242-1.845, P=0.036), LVEDD(OR: 5.281, 95%CI: 2.782-10.018, P=0.018), LVESD(OR: 4.735, 95%CI: 2.240-8.062, P=0.020), E/A(OR: 3.546, 95%CI: 1.844-4.307, P=0.027), HSP27(OR: 1.844, 95%CI: 1.153-3.638, P=0.015)and Sgp130(OR: 3.064, 95%CI: 1.519-4.233, P=0.008). Spearman correlation analysis showed that HSP27 and Sgp130 had a negative correlation with LVEF as well as E/A(all P<0.01)and positive correlation with LVEDD, LVESD, NYHA(all P<0.01). Conclusions The dynamic changes of HSP27 and Sgp130 concentration may have a prognostic value for cardiac function on CHF patients. Key words: Heart failure; Cardiac function; HSP27 heat-shock proteins; Soluble glycoprotein 130; Prognosis