Abstract
Background: Estrogen expression levels may be associated with age and may affect keratinization of the hard palate. Keratinized epithelium expresses cytokeratin 5 and 14 in the basal layer. The aim of this study was to determine the correlation between the levels of salivary estrogen and number of cytokeratin 5-positive oral epithelial cells. Methods: A total of 30 female subjects were recruited and divided into children, adults and elderly (N=10 per group). Salivary estrogen levels and cytokeratin 5-expressing oral epithelial cells were assessed using ELISA and immunohistological methods, respectively. Data were analyzed using ANOVA with post hoc LSD test and Pearson’s correlation coefficient. Results: The results showed that both the number of cytokeratin 5-positive cells and the level of salivary estrogen were significantly higher in adults but decreased in the elderly, as compared with those in children (p<0.05). Furthermore, the levels of salivary estrogen were significantly correlated with the number of cytokeratin 5-positive cells (r=0.815). The ANOVA result showed significance difference cytokeratin 5 expression and estrogen level (p<0.05). The post hoc LSD test revealed cytokeratin 5 expression and estrogen level to be significantly different in children, adults, and elderly participants (p<0.05). Conclusions: These results suggest that the profile of salivary estrogen and oral epithelial cell-expressed cytokeratin 5 may be positively correlated with age and depend on age.
Highlights
Estrogens are known to be involved in both the female and male reproductive systems, as well as both physiological and pathological regulation of cells and tissues[1]
Since the levels of estrogen may be associated with oral epithelial keratinization[2], the aim of the present study was to assess whether the levels of salivary estrogen expression are statistically correlated with the number of cytokeratin 5-positive oral epithelial cells
The cytokeratin 5 positive staining could be observed in the cell nucleus and cytoplasm
Summary
Estrogens are known to be involved in both the female and male reproductive systems, as well as both physiological and pathological regulation of cells and tissues[1]. Since the levels of estrogen may be associated with oral epithelial keratinization[2], the aim of the present study was to assess whether the levels of salivary estrogen expression are statistically correlated with the number of cytokeratin 5-positive oral epithelial cells. The aim of this study was to determine the correlation between the levels of salivary estrogen and number of cytokeratin 5-positive oral epithelial cells. Results: The results showed that both the number of cytokeratin 5positive cells and the level of salivary estrogen were significantly higher in adults but decreased in the elderly, as compared with those in children (p
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