Abstract

Kinetic heterogeneity of [ 3H]methyl β-carboline-3-carboxylate (CCM) binding was used to distinguish two populations of benzodiazepine binding sites in synaptic membranes of rat cerebral cortex. Curvilinear dissociation plots of CCM binding revealed major high affinity and minor lower affinity populations with slow and rapid dissociation rates, respectively. β-Carbolines showed some selectivity to displace the higher affinity [ 3H]CCM binding. The selectivity decreased in the following order: CCM (inverse agonist), FG 7142 (partial inverse agonist), ZK 93426 (antagonist) and ZK 93423 (agonist). Regional selectivity of displacing potencies of these β-carbolines on [ 3H]flunitrazepam binding in cerebellar versus hippocampal membranes decreased similarly.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.