Correlation between “Qing Fei San Jie Wan” and key gene CTLA-4 in lung cancer

Abstract

Lung cancer is the most threatening malignant tumor to the health and life of the population. In the past fifty years, the incidence and mortality of lung cancer have increased significantly, and Chinese residents are facing a serious burden of lung cancer. The co-inhibitory molecule CTLA-4 on the surface of T cells is a glycoprotein expressed on the surface of active CD4 and CD8 positive T cells, which transmits inhibitory signals to T cells, has the effect of down-regulating or terminating T cell activation, and participates in Negative regulation of the immune system. “QingFeiSanJieWan” has the effect of enhancing the function and effect of the immune system, which is of great significance to the human body's fight against lung cancer, and has a certain promoting effect on the activation of T cells and other lymphocytes. The drug has different inhibitory effects on the expression of co-inhibitory molecule CTLA-4 on the surface of CD4+ and CD8+ T cells. Preventing CTLA-4 and then inhibiting the immune response effect of T cells, thereby enhancing the immune function, fighting against lung cancer cell antigens in the body, and providing new immunological ideas for the treatment and drug mechanism of lung cancer. Using “QingFeiSanJieWan” to treat CTLA The anti-resistance effect of -4 proves that the drug is of great significance to the therapeutic mechanism of lung cancer.