Correlation between poststroke depression in acute phase of ischemic stroke and stroke recurrence at 1 year

Abstract

Objective To investigate the correlation between poststroke depression (PSD) in acute phase of ischemic stroke and stroke recurrence at 1 year. Methods Consecutive patients with acute ischemic stroke were enrolled prospectively. Hamilton Depression Rating Scale and 1 year follow-up were conducted. Multivariate logistic regression was used to identify the independent correlation between stroke recurrence and PSD. Results A total of 331 patients with acute ischemic stroke were enrolled, in which 115 patients (34.7%) with PSD, 37 (11.2%) had stroke recurrence in 1 year follow-up period. There were no significant differences in demography and baseline clinical data between the PSD group and the non-PSD group. The age (66.9±11.7 years vs. 59.7±11.7 years; t=3.621, P<0.001), systolic blood pressure (140.0 [133.5-150.0] mmHg vs. 135 [127.0-146.0] mmHg; Z=2.302, P=0.021), as well as the proportions of patients with atrial fibrillation (24.3% vs. 9.5%; χ2=7.251, P=0.007), diabetes (51.4% vs. 28.6%; χ2=7.956, P=0.005) and PSD (17.4% vs. 7.9%; χ2=6.852, P=0.009) in the stroke recurrence group were significantly higher than those in the non-recurrent group. Multivariate logistic regression analysis showed that PSD was an independent predictor of stroke recurrence after adjusting for age, systolic blood pressure, total cholesterol, atrial fibrillation, and diabetes (odds ratio 2.15, 95% confidence interval 1.19-5.45; P=0.016). Conclusion PSD in acute phase of ischemic stroke is independently correlated with stroke recurrence at 1 year. Key words: Stroke; Brain Ischemia; Depression; Recurrence; Risk Factors