Abstract

Genotypes of estrogen receptor gene (ER) α and β in 110 patients with non-alcoholic fatty liver disease (NAFLD) and 100 control subjects were examined by polymerase chain reaction-based restriction fragment length polymorphism.The haplotype analysis was conducted by SHEsis on-line computing platform.The results showed that there were no differences in the genotype frequencies and allele frequencies of ERα at Xba Ⅰ and Pvu Ⅱ enzyme cutting sites between two groups (P > 0.05).There existed significant differences in the genotype frequencies and allele frequencies of ERβ at Rsa Ⅰ and Alu Ⅰ enzyme cutting sites between these two groups (P < 0.05 or P <0.01).The risk of NAFLD in postmenopausal women with R or a allele was 1.833 (95% CI1.209-2.779,P<0.05)or 1.782 (95% CI 1.037-3.061,P<0.05) fold of that with allele r or A.The frequency of r-A haplotype in ERβ was significantly lower in NAFLD group than that in control group (OR =0.529,95% CI 0.348-0.805).Logistic regression analysis showed the relationship of fasting blood glucose,triglyceride,body mass index,diastolic pressure,Alu Ⅰ genotype with NAFLD (all P<0.01).The risk of NAFLD in postmenopausal women with Aa/aa genotype was 1.345 (95% CI 1.028-2.505,P<0.05) folds of that with AA genotype. Key words: Estrogen receptors ; Polymorphism, single nucleotide ; Non-alcoholic fatty liver disease

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