Abstract
BackgroundThe relationship between phospholipase C ε‐1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta‐analysis to obtain a more credible conclusion.MethodsPubMed, Medline, and Embase were systematic searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.ResultsA total of 27 studies were finally included. Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72–0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12–1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11–1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74–0.88) and gastric cancer (recessive model: p = 0.001, OR = 1.27, 95% CI 1.10–1.47; allele model: p = 0.03, OR = 0.88, 95% CI 0.78–0.98) in overall population. Further subgroup analyses showed that the positive results were mainly driven by the East Asians. However, no positive results were detected in Caucasians and West Asians.ConclusionOur findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians.
Highlights
Digestive tract cancer refers to malignancy that occurs in the digestive tract
Excessive alcohol intake, high consumption of red meat, and chronic viral infection were already identified as potential pathogenic factors of digestive tract cancer (El‐Zimaity et al, 2018), the fact that a great inter‐ individual variability in disease susceptibility existed in these exposed to above‐mentioned carcinogenic factors indicated that genetic background is vital for the development of digestive tract cancer
Among included studies for PLCE1 rs2274223 variant and digestive tract cancer, fifteen studies were about esophageal cancer (7,907 cases and 12,141 controls), ten studies were about gastric cancer (9,783 cases and 9,904 controls) and four studies were about colorectal cancer (1,040 cases and 1,314 controls)
Summary
Digestive tract cancer refers to malignancy that occurs in the digestive tract. Phospholipase C ε‐1 (PLCE1) cleaves phosphatidylinositol‐4,5‐bisphosphate to generate inositol. Some pilot studies were already conducted to investigate possible correlations between PLCE1 rs2274223 variant and the likelihood of digestive tract cancer. The results of these studies were controversial, especially when they were conducted in different ethnicities (Ezgi, Merve, Hakan, & Gül, 2016; Palmer et al, 2012; Yang et al, 2012). We conducted this meta‐analysis to better analyze the roles of PLCE1 rs2274223 variant in digestive tract cancer
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