Correlation between plasma renin concentration and plasma renin activity assays on the Maglumi 800 chemiluminescence immunoassay analyzer

Abstract

The ratio of plasma aldosterone concentration to plasma renin activity (PAC/PRA) is the most common screening test for primary hyperaldosteronism, but it is not standardized among laboratories. We evaluated the correlation between plasma renin concentration (PRC) and plasma renin activity (PRA), and then PAC/PRC and PAC/PRA ratios on Maglumi 800 immunoassay analyzer. Forty-five plasma samples from volunteers were collected. PRC, PRA and PAC were measured by Maglumi 800 - a fully-auto chemiluminescence immunoassay analyzer. Correlation between plasma renin concentration (PRC) and plasma renin activity (PRA), and then PAC/PRC and PAC/PRA ratios were determined by regression analysis. PRC and PRA showed a good correlation (r = 0.88). The PAC/PRC and PAC/PRA ratios have a similar relationship (r = 0.757). Because of the advantages of the procedure and the independence of PRC from endogenous angiotensinogen levels, PRC may be used preferentially over PRA as high throughput screening tool.