Correlation between plasma lncRNA CASC11 and malignancy in lung adenocarcinoma patients and the prognostic value of lncRNA CASC11.

Abstract

Objective: To study the connection between lncRNA CASC11 plasma expression and clinical characteristics as well as prognoses of patients. Methods: Sixty lung adenocarcinoma (LUAD) patients and 60 healthy adults participated in this research. LncRNA CASC11 expression was detected by quantitativereal-time PCR and the relationships between lncRNA CASC11 plasma expression and patientprognosis and clinical characteristics wereanalyzed. Results: LncRNA CASC11 was highly expressed in LUAD tissues and plasma (p<0.05). Receiver operating characteristic curve analysis indicated the diagnostic value of lncRNA CASC11 in LUAD (p<0.0001). Higher plasma lncRNA CASC11 expression indicated worse patient prognoses (p<0.05). Plasma lncRNA CASC11 level was also closely related to tumor differentiation and tumor-node-metastasis stage (p<0.05). Conclusion: Plasma lncRNA CASC11 may be a potential biomarker for LUAD diagnosis and prognosis.