Abstract
Objective: The purpose of this systematic review was to overview studies related to the relationship between periodontitis and the severity of COVID-19.
 Method: This systematic review and meta-analysis aims to see an overview of studies related to the relationship between periodontal disease and the severity of COVID-19, especially hospitalization. From the systematic review, 12 pieces of literature are included in the eligibility criteria and analyzed (9 reviews and three meta-analyses).
 Results: The estimated OR is 2.68 (z test p = 0.006), moderate heterogeneity is 61%. The periodontal treatment for patient COVID-19 were considered to prevent the death and severity of COVID-19.
 Conclusion: Periodontal disease had been associated with the severity and mortality of COVID-19, even though the further studies are needed to generalize to other populations. Apart, we hope that COVID-19 patients, get more attention for their periodontal tissue conditions, in order to prevent the death and severity of these patients.
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