Abstract
BackgroundTo systematically evaluate the correlation between percutaneous transthoracic needle biopsy (PTNB) and recurrence in stage I lung cancer.MethodsThe databases of PubMed, EMbase, The Cochrane Library, CNKI, WanFang Data and China Biology Medicine disc were retrieved to collect relevant literatures about the correlation between PTNB and recurrence in stage I lung cancer. The retrieval time was limited from the time of their database establishment to April 30/2020.Screened the literature, extracted the data and assessed the quality of studies included. Then the meta-analysis was performed by using Stata l6.0 software.ResultsA total of 8 cohort studies involving 2760 lung cancer patients were included. The results of meta-analysis showed that PTNB did not increase the risk of total recurrence and pleural recurrence in the patients with stage I lung cancer. The result of subgroup analysis is according to the tumor location. For stage I lung cancer, PTNB will increase the risk of pleural recurrence in patients with sub-pleural lesions but not in those without sub-pleural lesions.ConclusionsTo stage I lung cancer, PTNB is not associated with the total recurrence and pleural recurrence but PTNB will increase the risk of pleural recurrence in patients with sub-pleural lesions.
Highlights
To systematically evaluate the correlation between percutaneous transthoracic needle biopsy (PTNB) and recurrence in stage I lung cancer
The total relative risk ratio (RR) was 1.055, indicating that there was no significant correlation between PTNB and the total recurrence rate of stage I lung cancers
The results indicate that for stage I lung cancers, PTNB will increase the pleural recurrence rate in patients with sub-pleural lesions
Summary
The databases of PubMed, EMbase, The Cochrane Library, CNKI, WanFang Data and China Biology Medicine disc were retrieved to collect relevant literatures about the correlation between PTNB and recurrence in stage I lung cancer. The retrieval time was limited from the time of their database establishment to April 30/ 2020.Screened the literature, extracted the data and assessed the quality of studies included. Literature inclusion and exclusion Study type Randomized controlled study and cohort study. Study subjects Patients with stage I lung cancer. Exclusion criteria 1 No PTNB study was conducted; 2 letters, repeated publications, animal experiments, case reports, literature reviews, conference posters, conference abstracts and seminars; 3 four grid table values could not be obtained; 4 articles not published in English or Chinese and studies published in national journals of nonEnglish speaking countries. Search strategies Databases: PubMed, EMBASE, the Cochrane Library, CNKI, CBM and Wanfang database. Taking PubMed as an example, the retrieval strategy is as follows:
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
