“CORRELATION BETWEEN OXIDATIVE STRESS MARKERS AND DIABETIC CATARACT”

Abstract

Reactive oxygen species causes oxidation that interferes with the physiological processes of the cell. Oxidative stress is dened as an “imbalance between reactive oxygen species production and breakdown by endogenous antioxidants. It causes hazardous events such as lipid peroxidation and oxidative DNAdamage. The reactive oxygen species (ROS), which consist principally of molecules like the superoxide anion (O2 −), hydrogen peroxide (H2O2), and hydroxyl radicals, are detoxied by enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Different factors such as aging, drug actions and toxicity, inammation and chronic metabolic disorders like diabetes the production of ROS far exceed the capacity of antioxidants to neutralize. Due to oxidative stress, pancreatic β cell function may be affected, which, given the impaired expression of antioxidant enzymes, is outstandingly sensitive to reactive oxygen species. Oxidative stress in diabetes causes the over production of superoxide radicals in endothelial cells of large and small vessels, as well as in the myocardium and leads to many micro and macro vascular complications. The use of antioxidants, especially those with multiple antioxidant biomolecules like vegetables, fruits and seeds can be effective in preventing complications of diabetes.