Abstract
Background: Diabetic Nephropathy is consider as one of the major micro-vascular problems of diabetes mellitus and has become the most general single factor of end stage of kidney disease. It is defined traditionally by kidney morphological and modification like: glomerular hyper filtration, glomerular and kidney hypertrophy, increased urinary albumin excretion (> 300 mg/24 hours), increased GBM (Glomerular Basement Membrane) thickness and mesangial expansion and also accumulation of extracellular proteins comprising laminin, collagens and fibronectin worldwide. Oxidative stress (OS) has been characterized as the imbalance between reactive oxygen species (ROS) yielding and the possessive antioxidant defense system.
 Objective of the study: Correlation between oxidative stress and antioxidant in diabetic nephropathy.
 Materials and methods: The investigation was conducted on 100 DN subjects of both sex and aged 20 or more and 100 age and sex matched healthy control subjects. MDA, SOD and Catalase of each subject was measured.
 Results: the present investigation shows that the MDA was elevated significantly and SOD and Catalase level was found to be significantly low in DN individuals as compared to controls. Conclusion: This study concluded that the MDA could be better marker for early recognition of DN.
 Keywords: Diabetic nephropathy (DN), MDA, SOD, Catalase, Kidney disease
Highlights
Diabetic Nephropathy (DN): DN is treated as one of the chief micro-vascular complications of diabetes mellitus and has become the most commonly single factor of end-stage of kidney disease
The oxidative stress developed by hyperglycemia increases reactive oxygen species (ROS) production, which causes the activation of different redox‐sensitive cell signaling molecules and the production of cytotoxic materials
The mean MDA concentration was found to be significantly higher and super oxide dismutase (SOD) and CAT level was found to be significantly low in the DN as compare to control group
Summary
Diabetic Nephropathy (DN): DN is treated as one of the chief micro-vascular complications of diabetes mellitus and has become the most commonly single factor of end-stage of kidney disease. The oxidative stress developed by hyperglycemia increases ROS production, which causes the activation of different redox‐sensitive cell signaling molecules and the production of cytotoxic materials. This is followed by cellular dysfunction and damage and results in diabetic micro‐.and macro‐vascular complications[9,10,11]. Increased production of MDA level in the diabetic nephropathy, which is a suggestive feature of oxidative stress in long standing type 2 diabetes[17,18,19]. The present investigation was undertaken to find out level of MDA and SOD & CAT in DN & compared with a group of healthy subjects
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