Correlation between ovarian morphology and biochemical and hormonal parameters in polycystic ovary syndrome

Cihan Inan,Cihan Karadağ

doi:10.12669/pjms.323.10082

Abstract

Objective:To determine the biochemical and hormonal differences in polycystic ovary syndrome (PCOS) patients with and without polycystic ovary (PCO) morphology and to evaluate the outcomes resulting from those differences.Methods:The study included a total of 83 patients with PCOS; 43 of them had PCO morphology (Group-I) and 40 did not (Group-II). Serum LDL, HDL, total cholesterol, triglyceride (TG), total testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH), 17b-estradiol (E2), prolactin (PRL), thyroid stimulating hormone (TSH), sex hormone binding globulin (SHBG), glucose and insulin levels were determined. Homoeostatic model assessment insulin resistance (HOMA-IR) index was calculated.Results:The two groups were similar with respect to BMI. The systolic and diastolic blood pressure measurements of Group-I were significantly lower (p<0.01). Serum mean level of LH (p=0.026) and the mean LH/FSH (p=0.001) level of Group-I were significantly higher than Group-II. The total cholesterol and triglyceride levels of Group-I were significantly lower (p<0.05, p<0.01). The mean HOMA-IR level of Group-I was significantly lower than Group-II (p=0.004).Conclusions:The group without PCO morphology had a higher risk than the other group in terms of increased insulin resistance, dyslipidemia and cardiovascular diseases due to effects of hyperandrogenism.

Highlights

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder in reproductive aged women[1] and characterized by oligo or anovulation, hyperandrogenism
Studies have reported considerably different rates in terms of the incidence of polycystic ovary (PCO) morphology in patients with PCOS6 and there are inconsistent results regarding the effects of PCO morphology in polycystic ovary syndrome (PCOS) patients
We found that the group with positive PCO morphology had an increased ratio of luteinizing hormone (LH)/follicle stimulating hormone (FSH)

Summary

Introduction

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder in reproductive aged women[1] and characterized by oligo or anovulation, hyperandrogenism 1. Dr Cihan Inan, Department of Obstetrics and Gynecology, Kulu State Hospital, Konya, Turkey. 2. Dr Cihan Karadag, Marmara University Pendik Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey. Correspondence: March 1, 2016 April 27, 2016 May 5, 2016 biochemical) and presence of polycystic ovaries.[2] The most common symptoms include hirsutism, irregular menstrual cycles, infertility problems, insulin resistance, dyslipidemia, hypertension, type-2 diabetes, coroner artery diseases and increased rates of metabolic syndrome.[3,4]. Studies have reported considerably different rates in terms of the incidence of polycystic ovary (PCO) morphology in patients with PCOS6 and there are inconsistent results regarding the effects of PCO morphology in PCOS patients

Methods

Results

Discussion

Conclusion