Abstract
The aim of this study was to evaluate the correlation between marginal gingivitis, oral hygiene parameters, and interleukin-6 (IL-6) levels in gingival crevicular fluid of 40 children. The marginal periodontal pathology was evaluated by gingival index (GI). The status of oral hygiene was estimated by using patient hygiene performance (PHP), brushing frequency (BF), and plaque index (PI). IL-6 levels in gingival crevicular fluid were measured to evaluate the inflammation in marginal gingiva. PHP score showed a significant correlation with GI, BF, and PI. The groups based on PHP ranges were significantly related to IL-6 concentration in crevicular fluid.
Highlights
Cytokines are small proteins with autocrine, paracrine, and endocrine signaling functions [1].Interleukin-6 (IL-6) is a cytokine with pro- and anti-inflammatory effects, involved in inflammation response and in regenerative processes [2]
The focus of our research was to study the correlation between individual oral hygiene performance quality (PHP) and IL-6 levels in crevicular fluid
A poor oral hygiene performance quality in children could lead to plaque accumulation, which induces gingival inflammation and could increase inflammatory biomarkers concentrations in oral fluids
Summary
Cytokines are small proteins with autocrine, paracrine, and endocrine signaling functions [1]. Interleukin-6 (IL-6) is a cytokine with pro- and anti-inflammatory effects, involved in inflammation response and in regenerative processes [2]. Human IL-6 is a helical-shaped protein made up of 212 amino acids, and it belongs to the IL-6 cytokines family [3]. IL-6 is produced by T-cells and macrophage cells that induce immune response [4]. The variation in IL-6 levels in different oral diseases has already been evaluated; inflammatory diseases such as periodontitis and oral lichen planus can induce an increase in cytokines levels [5]. Especially in active state, can induce a significant increase in crevicular fluid IL-6 levels in children [6]
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